Biopolymers, or polynucleotides, are an innovative material for rejuvenation and deep restoration programs in injection cosmetology. Thanks to high-molecular organic biocompounds, which play an important biological role in the body, it is possible to prevent the development of signs of aging and solve a number of aesthetic problems without plastic surgery.
Before deciding to carry out polynucleotide anti-age therapy, it is necessary to familiarize yourself with the types of drugs, indications and contraindications, as well as the features of injection procedures.
What are polynucleotides
Polynucleotides in injection cosmetology and medicine are essentially biopolymers of natural or synthetic origin, consisting of nucleotide or mononucleotide residues. Their main function is to ensure the safety, implementation and subsequent transfer of genetic information. Low molecular weight compounds are used in cosmetology.
According to their natural structure, polynucleotides (PDRN) are one of the fragmentary parts of the DNA molecule with its multidirectional beneficial properties that affect all the most important processes occurring in the cells of the body.
According to research, the use of low molecular weight DNA, devoid of genetic information and not exceeding 500 KDa, is safe, since it does not cause genetic transformations.
During testing of the first samples of polynucleotide compositions in cosmetology, the effectiveness of the drugs was confirmed, and a positive effect on the composition of cells and intradermal structures was noted. For innovative booster drugs, the necessary compounds are synthesized from organic matter.
The production uses an extract from the DNA of the gonadal tissues of male salmon fish. It has been confirmed that the DNA of milk is similar to the DNA of human leukocytes in structure and properties. For this reason, elements synthesized for cosmetology have a positive effect.
The vitamin and structural composition of milk is rich in nucleic acids and proteins, which are actively used in the field of medicine and cosmetology. Such booster drugs practically do not cause negative symptoms or allergies after a course of injections, and their safety for the human body has been confirmed.
Indications for the use of polynucleotides in injection cosmetology
Through injection therapy with nucleotide drugs, a number of aesthetic problems can be solved:
- eliminate wrinkles of all types, as well as stop the process of formation of new ones;
- get a powerful lifting effect;
- restore elasticity and firmness lost under the influence of external and age factors;
- activate fibroblasts for accelerated synthesis of collagen-elastin fibers;
- smooth out the skin texture by restoring the intradermal layers;
- restore the hydrobalance of the epidermis, moisturize the internal tissues;
- eliminate inflammatory processes, accelerate healing processes;
- eliminate stretch marks, post-acne marks, scars and cicatrices;
- enhance tissue metabolism to strengthen the skin structure;
- remove waste and toxins, improve complexion;
- tighten the skin, eliminate signs of gravitational ptosis and rosacea.
Injection therapy with polynucleotide preparations is used for bioreinforcement and is effective for fine-wrinkled type of aging with thinned, moisture-deprived, sagging skin. The technique provides sustainable protection against the effects of free radicals and ultraviolet radiation, preventing photoaging, increasing the stress resistance of the skin.
Such acids in cosmetology are called “smart”; they are able to fight for youth, restoring damaged DNA and stimulating all the most important physiological processes. As a result of such activation by injection with drugs containing polynucleotides, a self-rejuvenation mechanism is launched in the body.
Possibilities of polynucleotides in activating the work of skin cells
Polynucleotides are an innovative, effective solution in correction and rejuvenation programs. In injection cosmetology, preparations with polynucleotides are in some cases superior to most beauty industry techniques in terms of the strength of the effect obtained. This result is achieved through tissue renewal at the DNA level.
Newly formed cellular compounds replace damaged nitrogenous bases, activating the process of rejuvenation of the skin and the entire body. The effectiveness and capabilities of the drugs at the stage of preclinical studies were studied in a test system, which is a culture of epidermal cells.
The following was revealed:
- When drugs are administered intradermally, the entire complex actively influences cellular metabolism.
- The synthesis of proteins inside DNA cells is accelerated by more than 2 times. The aesthetic result can be more pronounced if a highly concentrated polynucleotide composition is used.
- The resulting result of cellular stimulation is distributed through the formation of immunocompetent epidermal cells, which has a positive effect not only on the condition of the epidermis, but also on the entire immune system in general.
Polynucleotides in aesthetic cosmetology are classified as “prodrugs” that are capable of supplying cells with mitogenic deoxyribonucleotides, deoxyribonucleosides, and nitrogenous bases.
The use of injection techniques with compositions based on polynucleotides is considered one of the most promising areas in the field of comprehensive rejuvenation, correction of pronounced signs of chrono- and photoaging.
Patient reviews
On the Internet it is difficult to find reviews of real patients who used Beatrice drugs. But there are descriptions of the use of biorevitalizants similar in composition.
The review indicates the need to select a drug with a doctor, and not based on someone else’s experience.
The user describes the healing period and asks how long it will last.
The participant is interested in the specifics of the technique.
Other reviews can be found on the forum
Contraindications and safety of injections with PDRN
Despite the proven safety for the body, there are a number of contraindications to the use of injection techniques based on polynucleotide acids.
Therapy is not recommended:
- under the age of 18;
- with diabetes mellitus in the decompensation stage;
- in case of signs of rheumatoid changes with connective tissue damage;
- in the presence of autoimmune, infectious and viral diseases;
- for mechanical damage, inflammation of the skin in the injection area;
- in the presence of malignant neoplasms;
- during pregnancy and lactation;
- in case of acute intolerance to the components of the drug.
It is not recommended to carry out intradermal injection therapy if there are signs of hemophilia and the patient is taking medications that affect blood clotting.
In general, the safety of the drugs is clinically proven.
Anti-aging polynucleotide compounds do not cause:
- acute allergic reactions;
- toxicity;
- genetic transformation.
Before injection sessions, a qualified cosmetologist will identify any contraindications and, if there is the slightest doubt about safety, may recommend consultation with a specialist.
Healing period
Despite the fact that the cosmetic procedure is not a surgical operation, it necessarily includes a recovery period. The face looks swollen, there is pain, sensitivity, and redness. During this period, it is important to follow medical recommendations to prevent side effects and speed up healing.
Recovery rules:
- During the day, limit touching the skin, use gentle foam for washing;
- for the first 48 hours, apply anti-inflammatory agents recommended by your doctor;
- During the week you cannot visit the sauna, solarium, swimming pool, avoid alcohol, reduce salt intake;
- Physiotherapeutic and cosmetic procedures are not recommended;
- about 2 weeks you should not carry out implantation, surgery, chemical peeling;
- It is important to protect the skin from exposure to ultraviolet radiation and use special products.
The result lasts from several months to a year. The rate of elimination of the drug depends on the composition, individual characteristics, and lifestyle of the patient.
Injections with polynucleotides and hyaluronic acid
Polynucleotides in injection cosmetology, as well as hyaluronic acid, are highly effective drugs for anti-age programs. The decision to use a particular composition is made by a cosmetologist after consultation, examination, analysis and assessment of the aesthetic problem.
The main differences in the mechanism of action on the dermal space are presented in the table:
| Impact criterion | Injections with hyaluronic acid | Injections with polynucleotides |
| Operating principle | Restoration of hydrobalance with deep hydration and activation of fibroblasts for their own neocollagenesis | Stimulation of cellular metabolic processes with restoration and activation of division. Renewed fibroblasts, keratinocytes, and hyaluronate are produced in the layers of the skin. For self-rejuvenation. Promotes binding of free radicals, provides powerful UV protection |
| Application areas | Used to rejuvenate all facial areas, problem areas and body. In the periorbital zone, it is administered with caution, strictly according to indications | Can be used on all areas of the body, face, scalp |
| Development speed | The primary effect can be observed immediately after the session, the final result appears progressively after 2-3 weeks | The physiological mechanism is more complex; it takes several days for the first visible aesthetic results to appear |
| Number of procedures | 4-5 | 3-5 |
One of the main differences between hyaluronate in boosters is that polynucleotides help increase the number of dermal structures through a natural physiological effect, providing a prolonged result.
Due to the activation of the functional and reparative properties of skin structures, polynucleotide compositions of drugs ensure the activation of the process of its own biorevitalization and bioreparation.
Despite some differences, the substances are “friendly”, so most beauty products for injection anti-aging therapy use the synergy of hyaluronate and polynucleotides. This composition allows you to achieve the most visible and lasting rejuvenation effect, since one of the properties of polynucleotides is to enhance the effect of hyaluronic acid.
Changing lip volume
With the help of injections of drugs containing hyaluronic acid, you can achieve significant changes in appearance. The most popular procedure in aesthetic medicine is changing the volume and shape of the lips.
This service is used not only by young women who want to make their lips more sexy, but by people of all ages who are faced with the following problems:
- purse string wrinkles;
- drooping corners of the mouth;
- disproportion;
- curvature of the lip line.
Using hyaluronic acid, you can change the shape of your cheeks, cheekbones or chin, which makes your facial features more harmonious.
Hyaluronic acid is superior to other drugs for increasing lip volume and has the following advantages:
- naturalness _ After the procedure, the lips become voluminous, but without excessive plumpness, and their contour is clearer;
- facial expressions are not disturbed;
- there are no complications , because hyaluronic acid is as friendly as possible to the body;
- rejuvenation of the skin of the lips occurs due to the stimulating effect on metabolic processes.
The effectiveness of anti-aging injections with polynucleotides
The main characteristics of “smart” acids, which are valued in the beauty industry, are:
- Stimulation of fibroblasts.
- Activation of neocollagenesis with the synthesis of new collagen molecules.
- Stimulating the production of one's own nucleic acid.
- Improving the regenerative properties of internal tissues.
- Activation of the process of recycling the skin’s own nucleotides.
Thanks to these properties, the following effectiveness of anti-aging injections with polynucleotides is noted:
- bioreparation is stimulated;
- re-epithelialization and scarring of the skin are accelerated;
- normalization and acceleration of the formation of granulation tissues is ensured;
- metabolic cellular activity increases;
- angiogenesis is stimulated;
- the moisturizing effect of hyaluronic acid is enhanced;
- the level of the pro-inflammatory cytokine TNFa decreases.
Polynucleotides are biological traps that prevent the penetration of free radicals and protect cellular structures from various damages. They create lasting protection against ultraviolet radiation.
Preparations based on polynucleotides
Polynucleotides in injection cosmetology are used as monotherapy in rejuvenation programs or in synthesis with other active substances. Manufacturers offer several types of drugs, the action of which is aimed at solving a particular set of aesthetic problems.
All compositions have a dense gel structure, are plastic, safe, and practically do not cause adverse reactions. Sessions are conducted by qualified cosmetologists in a salon or clinical setting.
The most popular drugs with polynucleotides:
- NEWEST. It is used to correct age-related changes, enhances tone, restores elasticity to the epidermis, healing from the inside at the cellular level. The average cost of 2 ml of the drug is from 5300 rubles.
- PLINEST FAST. Fast-acting composition, suitable for young skin, subject to frequent stress, with fine-wrinkled aging. The composition is non-toxic to the cellular structure, biocompatible with internal tissues. Allows you to eliminate traces of early withering, the effect of stressed skin, sagging, atony. The average cost in specialized stores is 7,800 rubles.
- Renaissance System-1. A biological product with a polynucleotide complex helps to thicken thin, moisture-deprived skin, replenish tissue volume, and perform bioreinforcement in order to activate neocollagenesis in the body. The cost of the procedure with the drug (1 ml) is from 9,700 rubles.
- TwAc and TwAc 3.0. A popular booster in cosmetology, it is used for compaction, rejuvenation, activation of cellular processes, and renewal of dermal structures. Twice has a stimulating, immune-strengthening effect, containing polydeoxyribonucleotides and stabilized hyaluronate. The complex of useful acids allows you to solve a number of aesthetic problems in various different areas of the body and face. The average cost of a booster is from 5,500 rubles.
- PLINEST BODY. Intradermal pyrogen-free gel of liquid consistency is intended for the correction of problem areas of the body. Can be used in the area of the buttocks, neck, décolleté, as well as in trichology to restore the scalp. The price of one package (5 ampoules) is from 6,000 rubles.
This or that composition can be used for various purposes:
- for boosterization of the skin;
- for correction of the periorbital zone;
- in biorevitalization programs;
- for rejuvenation.
The drug is selected and prescribed by a cosmetologist according to individual indications.
For skin booster
A booster system based on drugs with polynucleotides allows:
- ensure maximum rehydration;
- improve turgor, increase elasticity, restore firmness and tone;
- provide protection from the negative effects of free radicals that destroy cellular structure;
- stimulate dermal regeneration;
- activate fibroblast metabolism.
The booster system allows you to improve the condition of the skin, tightening the tissue, restoring lost volume as a result of processes that destroy the cellular basis. The most effective booster is the drug TwAc 2.0, 3.0 with the synthesis of hyaluronate and polynucleotides.
For the skin around the eyes
During the process of photo- or chronoaging, the periorbial zone is most susceptible to negative changes. Thinning wrinkles, deprived of moisture and prone to the formation of a network of wrinkles, can be restored with the help of the polynucleotide preparation TwAc Eyes. This is a sterile, odorless and colorless gel solution based on a long-chain polynucleotide.
Indications for the use of polynucleotides for the eye area in cosmetology.
It allows:
- supply cells with a sufficient amount of mitogenic deoxyribonucleotides, deoxyribonucleosides and nitrogenous bases;
- improve the regenerating properties of the epidermis;
- enhance metabolism in cells;
- tighten and smooth the area around the eyes, as well as the décolleté and neck areas.
For biorevitalization
Polynucleotides are used in cosmetology for biorevitalization.
The procedures allow:
- restore the integrity of the matrix structure;
- enhance the function of fibroblasts to activate neocollagenesis;
- correct and prevent ptosis;
- reduce the severity of dermal and epidermal wrinkles.
As a rule, combined formulations with polynucleotides and hyaluronate are used for biorevitalization. The most effective boosters are TwAc and Renaissance.
For skin rejuvenation
For total rejuvenation of aging skin with visible changes, cosmetologists recommend using injections with Plinest.
Injection therapy for rejuvenation allows you to:
- revitaminize tissues;
- improve health and strengthen skin immunity;
- eliminate strong visible changes, hyperpigmentation; smooth out medium and deep wrinkles;
- eliminate signs of gravitational ptosis and other changes as a result of aging.
For a more pronounced and lasting result, it can be used as a hyaluronic acid enhancer; it has been used in anti-age programs since 45 years.
Progress of the procedure with polynucleic acids
A session of rejuvenation, biorevitalization or boosterization with boosters based on polynucleotides is carried out in several stages:
- First, the cosmetologist conducts a consultation, examination, and medical history. Determines the area in need of correction, selecting the optimal drug and dosage.
- Before injections, removes makeup, cleanses and disinfects the skin.
- To numb the most sensitive areas, topical anesthesia is used so that the session does not cause discomfort.
- He begins intradermal administration of the drug with a special medical needle for cosmetic injections, precisely treating the entire problem area.
- Apply healing ointment for faster recovery after an invasive procedure.
A rejuvenation session with polynucleotides takes no more than 60 minutes. The effect can be felt 4-7 days after the first injection. The recommended course for correcting aesthetic problems is determined by a cosmetologist. The interval between sessions of intradermal administration of the drug is 7-14 days.
After 6-12 months, to achieve a more stable and long-lasting effect, it is recommended to repeat the course.
To solve various problems, as well as to prevent aging, polynucleotides are used in injection cosmetology. The cost of the course depends on the type of drug, as well as on the qualifications of the cosmetologist and the area of correction.
How to minimize the effect
The procedure does not always achieve the desired results. There are also risks of developing side effects. The advantage of biodegradable fillers is the ability to correct the results of correction. To do this, the doctor chooses the removal technique, depending on the composition of the drug.
Traditionally, hardware procedures and lymphatic drainage massage are used. Hyaluronidase is used to remove hyaluron-based drugs.
The cosmetologist decides which method to prefer in each case individually. It is important to fill out an injection passport before carrying out the procedure; information about the volume, injection zones, and name of the drug will allow you to determine the optimal strategy.
