Bioreparant "Gialripayer". Reviews from cosmetologists, description of the procedure and effectiveness

Bioreparation is a cosmetic procedure whose purpose is to restore facial skin cells susceptible to aging processes and other negative environmental factors. The effect is achieved through the injection of active substances, which, staying in the dermis for a long time, contribute to its revival. The skin is naturally rejuvenated and takes on a healthy and fresh appearance. In the article we will look at the bioreparant “Gialripayer”, reviews of which will be presented to readers in detail.

Description of the drug

In terms of its properties, Hyalrepair belongs to chondroreparants. These are slow-acting (cumulative) substances that restore the structure of damaged cartilage fibers and help improve joint mobility. Russian pharmacologists classify Gialripayer as a third-generation chondroreparant, which is a combination product consisting of several components . All products in the Hyalrepair line are based on hyaluronic acid, a substance that is part of a large number of tissues and biological fluids of the human body, including nerve endings, ganglia, epithelium, saliva, vaginal lubrication and joint fluid.

Hyalrepair

The body of a person weighing 65 kg contains about 14 g of hyaluronic acid, but with age its reserves decrease, which negatively affects the condition of the skin, mucous membranes and osteochondral elements. Additional local administration of hyaluronate is necessary for persons who have suffered various injuries, have chronic joint diseases, and are daily exposed to heavy physical activity. With an acute shortage of this acid, not only does the resistance of joints to stress decrease, but also general dehydration of the body occurs, since hyaluronate molecules, binding to specific proteoglycan proteins, retain water, maintaining the elasticity of cartilage elements and skin.

4 reasons for aging

Hyalripayer preparations are produced in the form of a gelatinous jelly-like material (gel), packaged in syringes (1.5%) or vials (0.8%). Before packaging, the gel is sterilized in a special way, and a sticker is inserted into the blister, which then must be attached to the patient’s medical card indicating the concentration, dosage of the administered substance, as well as the date and time of administration.

The product must be stored at room temperature, avoiding overheating (above 25°C) and freezing. After opening the bottle, it is permissible to store the gel in the refrigerator for 12 hours.

Biorevitalization areas

Note! The gel in a syringe or bottle must have a uniform consistency (the drug has no color and must be completely transparent). The presence of sediment, flakes, lumps, as well as clouding or yellowing of the gel is a contraindication for use and may indicate improper storage, damage to the packaging or expiration.

Facial bioreparation

A little about the manufacturer

The line of drugs for bioreparation was developed in Moscow through long research work. The effectiveness of the products has been clinically proven by the Moscow Institute of Plastic Surgery and confirmed by the Academy of the Russian Academy of Sciences. – Russian laboratory “Toscani”. When creating drugs, raw materials imported from Europe and Japan are used. The finished pharmaceutical product meets all the requirements of standards not only of the Russian Federation, but also of the EU countries.

A series of products are registered as drugs for medical purposes. The substance is released in vials or directly in injection syringes. Use is recommended only with the help of a qualified specialist. Distributor.

What's in it?

Hyalripayer is available in several dosage forms, differing not only in the concentration of the main active ingredient (hyaluronic acid), but also in composition.

Table. Composition of Hyalrepair preparations.

The effect of hyaluronic acid on joints

The preparations Gialripayer-2 and Gialripayer-10 differ from each other not only in composition, but also in the modification of hyaluronic acid, which is included in their composition. In Hyalripayer-2, hyaluronic acid is used in the form of sodium hyaluronate, modified with a copolymer of ascorbic acid and magnesium, which has pronounced antioxidant properties. In the production of Hyalripayer-10, zinc hyaluronate and sodium ascorbyl phosphate are used, which are characterized by higher biological stability and a strong anti-aging effect, which explains the high demand for this dosage form in the cosmetology industry.

Damaged skin and skin rich in hyaluronic acid

A stabilized form of highly purified hyaluronic acid is extracted by bacterial fermentation followed by the addition of highly active substances that enhance the effect of the main component: glycine, heterocyclic amino acids, vitamins, etc.

Benefits of Modified Hyaluronic Acid

Why is the usual polysaccharide structure so different from the modified one and what is the benefit of it? To begin with, this is the best method for creating a complex cosmetic preparation with hyaluronic acid, aimed not only at treating dehydration of the dermis, but also at providing high-quality skin care.

The main advantage is the resistance of the modified compound to enzymes of the hyaluronidase group, which break down hyaluronic acid, destroying its structure. The polysaccharide component “Hyalripayer” remains in the skin for up to 3 weeks and does not undergo enzymatic breakdown during this period, like the substances attached to it. This ensures a prolonged effect of the drug, deep hydration and nutrition of the skin.

Component Properties

The main component of Hyalripayer preparations is hyaluronic acid. This is the most important acid present in the human body and is necessary to maintain normal fluid balance and preserve the structure of bones, cartilage fibers, synovial fluid, epidermis, epithelial and connective tissue. It has a number of medicinal properties:

• participates in the processes of regeneration (restoration) and tissue renewal;
• ensures the synthesis of chondrocytes - the structural components of cartilage tissue;
• maintains the elasticity of the skin, ligaments and cartilage;
• ensures normal joint mobility;
• protects the skin from premature fading and aging, and also prevents the accumulation of radioactive and toxic elements in its surface and deep layers;
• interacts with cell surface receptors;
• participates in the formation of innate immunity in the fetus.

Advantages of bioremediation

It has been proven that maintaining sufficient molecular weight of hyaluronate in cartilage tissue in people over 40 years of age significantly reduces the risk of fractures and degenerative damage to the musculoskeletal system, and adequate supply of hyaluronic acid prevents the development of skin tumors (including malignant neoplasms).

The amino acids and ascorbic acid included in Hyalripayer preparations also have antioxidant, immunostimulating, anti-inflammatory and bioreparative effects. Injections of Hyalrepair-2 and Hyalrepair-10 have a positive effect on the condition of the skin: its elasticity increases, the contour improves, and turgor pressure changes. Vitamin C stimulates the synthesis of collagen and elastin - the main elements of the skin that ensure its elasticity and prevent the early appearance of wrinkles.

Hyalrepair-2 and Hyalrepair-10 injections have a positive effect on skin condition

Important! With the local administration of Gialripayer preparations, a physiologically favorable environment is created for the natural stimulation of the metabolic activity of cells, that is, the effect of these chondro- and bioreparants is cumulative (prolonged).

Bioreparation reviews

What is important? Many separate studies were conducted on the drugs Gialripayer, Mezovarton R 199 and Mesoxanthin F 199. All of them were crowned with only good results and positive reviews from professionals.

Each clinic works with drugs from certain companies and has experience and its own developments on a specific drug. An experienced doctor will clearly determine the indications and advisability of using a particular drug, as well as the procedure for carrying out the procedure in each specific case.

Without a doctor’s individual approach to the patient’s problem, one should not expect good results.

Everything is good in theory, but what do we have in practice? A wide variety of client reviews about the bioreparation procedure.

My experience

To begin with, I will share my experience of using bioremedies, and only then I will post the reviews that I was able to find on other sites and forums.

So, the first thing I want to say is: don’t expect a super rejuvenating effect from bioreparation - it won’t happen!

I was given Gialripayer 04.

An obvious plus is getting rid of age spots: the manufacturer doesn’t lie here. True, the stains did not disappear instantly, but over a period of time (a month or a little more). The skin acquired an even light shade and began to look rested and refreshed.

The moisturizing effect is also present. With my dry skin, which requires constant application of a rich cream to reduce the feeling of tightness, I forgot about its existence for two months.

As for the wrinkles, they haven’t gone away: the small ones remain in place, but I don’t even want to remember the clearly noticeable ones. Yes, on the second day after the injections it seemed that my face had smoothed out, but later everything returned to normal.

Cons in my case:

• For the first three days, the face looked like a toad skin because of the papules, and they were bright red in color - not a pleasant sight. To prevent the development of infection, I treated the skin with miramistin (spray), although this is not necessary.

• I did not complete the entire bireparation course, as my cosmetologist recommended (4 procedures every three weeks). Why? After the second injection, extraneous swelling appeared, which took longer than usual, plus huge red spots formed under the eyes - I suspect that this is how an allergy to vitamin C manifested itself. Therefore, if you have increased sensitivity to citrus fruits, then it is better not to take risks with bioremedies containing ascorbic acid.

My conclusion : the procedure is good for young girls as a preventive measure against aging, but to solve age-related problems we need to look for more effective means. Although bioreparation is also suitable for older females to nourish, moisturize the skin, and get rid of pigmentation.

Reviews from other girls and women

I’ll say right away that I don’t trust all the responses posted below. But we cannot exclude the possibility that bioreparation actually helped someone get rid of fine wrinkles.

After two procedures, the skin of the face became moisturized, the feeling of dryness and parchment disappeared, after about a month I noticed that the skin was smoothing. I am 39. I took a course with Hyalripayer. In general, I am satisfied with the result: wrinkles have smoothed out, skin tone has increased, the skin in the cheek area has tightened, and the nasolabial lips are less pronounced. I look clearly younger. True, after the first procedure, lumps remained at the injection sites for about two weeks. After the injections, I could not leave the house for 3 days - my whole face was covered in red spots, and in some places there were bruises, plus also swelling under the eyes. I began to notice the effect of a slight smoothing out of wrinkles after about a week, and after two they became almost invisible. The tone of my face has evened out, there is no puffiness under the eyes. Now I am 42 years old. Before hyalripayer, I injected other drugs - the result was, although not what I expected. It’s been 2 weeks since I took this drug and I don’t really see any effect. The procedure is not worth the money spent. Completed the bioreparation course. I’m happy with the result, even despite the bruises, slight swelling under the eyes and a face like that of someone with chickenpox. All this took place within two days. After the third and fourth procedures there were no more bruises, and I recovered faster. Four months after the first procedure: the face is toned, not dry, a few visible wrinkles remain, the rest have disappeared, the skin color is even. Colleagues say that she looks 5 years younger.

Alas, despite all the advantages, bioreparation is not without its disadvantages, such as pain, invasiveness, high cost of the procedure, and the need for a rehabilitation period. It will not replace plastic surgery.

If we put these points aside, this is a good way to prolong the youth of the skin for women 30-40 years old, as well as a good addition to anti-age complex programs for older people.

If you decide to undergo this procedure, do not forget that you are entrusting your health and beauty to a cosmetologist, so do not be lazy to find out as much information as possible about the clinic, doctors, qualifications and reviews about them in your city.

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Indications for use

The nosological classification of chondroreparants based on modified stabilized hyaluronic acid contains a large list of indications for use (as part of complex therapy), which includes the following diseases and pathologies:

• neuropathies of the upper and lower extremities;

Ulnar nerve neuropathy

• spinal cord compression syndrome (including diagnostically unspecified forms);
• inflammation of skeletal muscles;
• injuries and surgical interventions on various segments of the musculoskeletal system (including during postoperative rehabilitation);
• damage to the capsular ligamentous apparatus;
• carpal tunnel syndrome (if it is necessary to relieve trigger points);
• dystrophy and degenerative lesions of ligaments, muscles, connecting elements, tendons and cartilage (inflammatory and non-inflammatory etiology);
• bursopathy;
• arthritis and arthrosis.

Arthritis

For the treatment of arthritis, arthrosis of the hip and knee joint, as well as post-traumatic arthrosis, Hyalripayer-10 is used in injection form (syringe) with a concentration of hyaluronic acid of 1.5%.

In cosmetology, the product is used to restore skin elasticity and treat wrinkles.

In cosmetology, the product is used for facial rejuvenation

Answers on questions

Is it possible to combine Hyalripayer with other procedures?

Cosmetologists recommend using the drug with chemical peeling. Cannot be combined with other procedures if 2 weeks have not passed since the end of the course.

A car accident left me with ugly scars on my face. Can Gialripayer help me get rid of them?

Without seeing it in person, it is difficult to assess the condition and size of the scars. The drug helps smooth out scars and scars with a duration of action of up to 9 months. A more detailed answer regarding the possibility of using the composition or its substitute can be given after a personal examination.

Is it possible to use biorevitarizant in summer?

In summer, you can take an anti-aging course, in winter - to eliminate the effects of sun exposure.

How long will injection marks remain on the body after bioreparation?

The effects of injections disappear on average within 3 days. If marks do not disappear after 3 days, you should contact your doctor for additional advice.

Let's sum it up

Hyalripayer has been successfully used in aesthetic medicine since 2009. Russian manufacturers managed to create a cosmetic product that is superior in quality and duration of action to imported analogues. Numerous reviews from specialists and patients confirm its positive results.

Do you have experience using this drug? Did you like the resulting effect, quality and duration of action? Share your opinion about the product, the procedure performed, the clinic, the doctor.

Application of bioreparants Hyalripayer in cosmetology

The products in the Hyalrepair line have not only medical, but also cosmetic indications for use. In cosmetology, the product is used as a biologically active bioreparant - a natural stimulator of skin renewal and rejuvenation processes. The choice of a specific solution is determined by the purposes of use and the clinical effect that is expected to be achieved after a course of injections.

Table. The result of using bioremedies Hyalripayer.

Note! All products in the Hyalripayer line are suitable for correcting age-related skin changes and skin rejuvenation.

Opinion of cosmetologists

Experts give advice to women on one or another rejuvenation procedure. The choice of bioreparation or biorevitalization directly depends on the condition of the skin.

The key point is the correct choice of specialist and salon/clinic for the procedure. The result and the absence of complications depend on professionalism and experience in working with different drugs.

How to use Hyalrepair?

Regardless of the form of release, Hyalrepair preparations are used for local (topical) administration directly to the affected area.

Types of Hyalrypyera

Gialripayer 0.8%

Preparations with a concentration of the active substance of 0.8% must be injected directly into the tendon canal or the area of ​​​​damage to the ligamentous apparatus. Before administration, the doctor must assess the degree of damage, as well as the condition of the surrounding soft tissue. In the presence of effusion (excessive accumulation of fluid), it is necessary to first drain the synovial cavity in order to remove excess fluid.

It is permissible to administer no more than 0.5 ml of solution at a time. The standard therapeutic dosage for musculoskeletal pathologies of moderate severity is 0.25-0.4 ml. The course of treatment is 1.5-2 months. The interval between injections is no more than two weeks.

The interval between injections should not exceed 2 weeks

Gialripayer 1.5%

The technique for administering the chondrorepair drug with a concentration of 1.5% is the same as for Hyalrepair 0.8%. Dosage per injection – 2 ml (1 full syringe). The interval between injections is 10-14 days. To achieve a stable therapeutic effect, it is recommended to complete the full course of treatment, which ranges from 1.5 to 2 months, that is, 3-4 injections need to be given in one course. Repeated treatment is carried out after 8-12 months, taking into account the dynamics of the changes that occur.

Note! Hyalripayer preparations do not have a systemic effect on the body and act only at the injection site.

The drug acts only at the injection site

Gialripayer 1.4%

Preparations with a hyaluronic acid concentration of 1.4% are administered once a week. The full course consists of three injections, that is, it lasts 14 days (the interval between injections is 7 days).

Gialripayer 0.6%

For the treatment of acne, xerosis of the skin, seborrhea of ​​the scalp, injections of Hyalrepair 0.6% are performed once every 2 weeks. To achieve a significant clinical effect, it is necessary to undergo at least three procedures. Pronounced health and cosmetic results are achieved after 4-5 procedures.

Dry facial skin

Mesolifting line

Mesotherapy products consist of injection solutions with low molecular weight hyaluronic acid (2 mg/ml). Hyalrepair-M is available in 5 ml bottles. It is recommended to use according to the following course of treatment: 6 procedures are performed at intervals of 7–10 days, after which 2 more procedures are performed once a month. The main treatment ends here. Maintenance procedures are used once every one and a half to two months.

The line of mesotherapy products consists of:

• Hyalrepair-06M – additionally contains vitamin C and B2. Recommended for use for the treatment of age-related changes and inflammatory processes, such as acne and post-acne, stagnant spots. Effective for dry and dehydrated skin.
• Hyalrepair-07M – consists of amino acids (cysteine, glycine, valine) and vitamin C. An ideal product for dry, sensitive and atonic skin. Eliminates sagging, restores water-alkaline balance, and also fights the first age-related changes.
• Hyalrepair-08M – contains L-carnitine and vitamin C, intended for correcting the face with fatty deposits and combating cellulite. Promotes lipid synthesis, thereby dissolving excessively accumulated fat.
• Hyalrepair-10M – consists of vitamin C, cysteine ​​and glutathione oligopeptide. Fights signs of photoaging and harmful environmental influences. Smoothes wrinkles, increases elasticity and overall skin tone. It is used for rosacea, hyperpigmentation, disorders due to smoking or stress.

As can be seen from the characteristics of the products, in the series you can find a product ideal for a specific skin type, type of disorder and the reasons for its formation. Users consider “Gialripayer” and “Hyalripayer Mesolift” to be a godsend among cosmetic pharmaceuticals. Reviews confirm this.

Portability

In most cases, when administered locally (perineural or periarticular), the drug is well tolerated by all groups of patients. In rare cases (mainly after intramuscular injections), patients reported pain, swelling, a burning sensation and allergic reactions at the injection site. During the day after the injection, a feeling of heat or warmth may also persist: such a reaction is normal if nothing else bothers the patient and does not require any corrective measures.

Important! Some patients ask to numb the injection site before administering the drug, which should never be done. Official instructions do not allow the administration of any drugs 72 hours before the injection and within 48 hours after the injection. This is necessary to achieve a stable therapeutic result, since the drug interaction of hyaluronic acid with other substances has not been well studied.

The main effects of the drugs in the line

General information

A line of drugs called Gialripayer was developed and released in Russia in 2009. The main difference between domestic cosmetic products is the use of hyaluronic acid (HA), which has undergone a specific modification. Solid phase processing allows you to change the structure while maintaining the basic properties and functions. At the same time, hyaluronic acid that has undergone chemical changes:

• combines effectively with peptides, beneficial acids and various vitamins;
• It is broken down more slowly by enzymes and remains in the dermis for approximately 3 weeks, allowing the maximum effect to be achieved.

The principle of operation of any Hyalrepair product is to slowly break down into components that help attract water molecules, hydration, increase local immunity, create a healthy environment for cell renewal, and optimize collagen synthesis.

Hyalripayer products are produced not only for bioreparation in a volume of 1.5 ml, but also for mesotherapy (5 ml of product in a syringe).

Possible contraindications

Limitations for the use of Hyalrepair chondrorepairs are associated primarily with the features of using the gel, and not with its composition, since hyaluronic acid is a natural component of body tissues and fluids and has extremely low rejection. Injections should not be administered to pregnant and lactating women, as well as to persons suffering from allergies or intolerance to any of the components of the drug.

The drug has its contraindications

Other contraindications may include:

• any history of autoimmune diseases (autoimmune hepatitis, antiphospholipid syndrome, Sharpe syndrome, acute disseminated encephalomyelitis);
• carrying out autoimmune treatment, as well as radiation or chemotherapy;
• diseases of the hematopoietic system, accompanied by pathological fragility of blood vessels and increased bleeding;
• infectious skin diseases;
• inflammatory diseases of the joints of septic etiology.

Histological study of the reaction of animal connective tissue to the introduction of modified HA formulas

It is not recommended to administer Hyalrepair gel material in case of severe intoxication syndrome, hyperthermia, signs of fever and systemic infections (bronchopulmonary diseases, infectious bone lesions, bacterial myositis, etc.).

Side effects

Complications are rare. Their appearance depends on the experience of the cosmetologist, the quality of the administered drug and the violation of the manipulation technology.

Possible negative consequences are:

• increase in smudges and hematomas;
• allergic reaction, itching, burning;
• introduction of infection;
• scar formation;
• tissue necrosis, vascular blockage.

The effect will be noticeable after 1-2 sessions. Hyaluron gradually fills wrinkles and smoothes the skin. Improvement in the appearance of the skin occurs 2-3 weeks after rejuvenating injections.

What should the patient know?

Injections Gialripayer-2 and Gialripayer-10 are prescribed mainly by a doctor. Before consenting to the procedure, the patient should familiarize himself with possible contraindications, as well as receive general instructions regarding preparation for the injection and behavior after the injection.

1. Throughout the entire course of treatment (about 6-8 weeks), the consumption of alcoholic beverages, even those with low ethyl alcohol content, is prohibited. Ethanol disrupts the process of cellular metabolism, which makes the therapy ineffective and pointless.

   
   The drug is quite expensive

2. The introduction of any medications (including drugs for local and systemic anesthesia) into the affected area is prohibited until the end of the course of treatment.
3. After the injection, it is necessary to follow a gentle regimen and limit the load on the damaged area. Ideally, you should maintain limited bed rest for 1-2 days after the injection.

   
   After the injection you should remain in bed

All medications that the patient takes regularly or took within two weeks before the injection must be reported to the attending physician.

Carrying out

Typically, a bioreparation course includes 3-5 sessions every two to three weeks. The exact amount is determined by the doctor, based on the selected cocktail and the patient’s skin condition.

Preparation

A week before the procedure, you must adhere to the following recommendations:

• exclude the consumption of alcoholic beverages - this prevents hyaluronic acid from remaining in the tissues;
• It is prohibited to carry out deep cleaning and similar aggressive measures;
• It’s worth taking a course of vitamins (prescribed by a specialist);
• apply products that prevent the appearance of bruises for a couple of days;

For frequent herpetic rashes, for prevention purposes, it is better to take Acyclovir.

How it goes

Bioreparation of facial skin requires compliance with important points:

• bioremediation quality;
• sterile conditions;
• doctor's experience.

The cosmetologist first opens the package, demonstrating to the client the integrity of its contents. Pay attention to the expiration date.

Stages of the procedure itself:

1. Cleansing the skin of cosmetics and dirt and treating with an antiseptic.
2. Application of an analgesic. It is left for half an hour. If all the rules are followed, no pain is felt during injections. If the patient wishes, this step can be skipped.
3. The drug is injected intradermally with a thin needle (in small doses). The punctures are made at a distance of 1 cm from each other. The area around the eyes is pierced especially carefully.
4. Repeated antiseptic treatment is carried out.
5. A sedative is applied, which enhances the effect of the injections.

Including anesthesia, the session lasts about an hour. At the end of the procedure, you are given a card with information about the drug (the name and number must be indicated).

Healing period

Woman looking at self in mirror.

The rehabilitation period lasts from 2 to 7 days. At this point, the normal reaction is considered to be:

• bruises, swelling and redness at puncture sites;
• papules (they will resolve differently, depending on the bioremediate chosen);
• slight soreness.

The swelling subsides within 24 hours, the papules disappear after 2-3 days.

During healing it is prohibited:

• sunbathe, visit the sauna, swimming pool and solarium;
• drink alcohol, smoke a lot;
• carry out peelings, massages and other cosmetic procedures;
• use decorative cosmetics;
• get involved in physical activity.

Buyanov Sergey Yurievich (Expert Doctor):

Violation of rehabilitation rules significantly affects the effectiveness of the procedure. Sweating during overheating and physical activity changes the biochemical composition of the skin surface, which can accelerate the biodegradation of hyaluronic acid.

Aftercare

After the procedure, you need to treat the wounds with an antiseptic for a week, and if hematomas appear, use a special ointment. Before going outside, you need to apply sunscreen.